INCREASED ACETAMINOPHEN USE APPEARS TO BE MAJOR CAUSE OF THE EPIDEMICS OF AUTISM, ADHD, and ASTHMA

 There have been several recent articles, even coming from the mainstream media about the possible dangers of acetaminophen (Tylenol) use both for children and for women who are pregnant.  Our Director, William Shaw, Ph.D. wrote an article on the research done on these potential dangers in 2013 that was originally published in the Journal of Restorative MedicineEvidence That Increased Acetaminophen Use in Genetically Vulnerable Children Appears to Be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma.  Dr. Shaw’s article has 84 references which include several studies and articles about this incredibly important topic and here is the article in full on our website, including those references:        

https://www.greatplainslaboratory.com/articles-1/2015/11/13/evidence-that-increased-acetaminophen-use-in-genetically-vulnerable-children-appears-to-be-a-major-cause-of-the-epidemics-of-autism-attention-deficit-with-hyperactivity-and-asthma?rq=acetamin

Dr. Shaw then presented a webinar to review the findings from his article and you may watch that below:

 

New Research Since Dr. Shaw’s Article Supporting These Findings:

September 2014:  Associations Between Acetaminophen Use during Pregnancy and ADHD Symptoms Measured at Ages 7 and 11 Years.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108210

October 2014:  Paracetamol: Not as safe as we thought? A systematic literature review of observational studies

http://ard.bmj.com/content/75/3/552.full

February 2016:  Paracetamol use in pregnancy and infancy linked to child asthma

https://www.ncbi.nlm.nih.gov/pubmedhealth/behindtheheadlines/news/2016-02-10-paracetamol-use-in-pregnancy-and-infancy-linked-to-child-asthma-/

April 2016:  From Painkiller to Empathy Killer: Acetaminophen (Paracetamol) Reduces Empathy for Pain

http://scan.oxfordjournals.org/content/early/2016/05/02/scan.nsw057

September 2016:  Maternal use of acetaminophen during pregnancy and risk of autism spectrum disorders in childhood: A Danish national birth cohort study.

https://www.ncbi.nlm.nih.gov/pubmed/26688372

September 2016:  Fenton-Like Catalysis and Oxidation/Adsorption Performances of Acetaminophen and Arsenic Pollutants in Water on a Multimetal Cu–Zn–Fe-LDH

http://pubs.acs.org/doi/abs/10.1021/acsami.6b08933

October 2016:  Association of Acetaminophen Use During Pregnancy With Behavioral Problems in Childhood - Evidence Against Confounding

http://jamanetwork.com/journals/jamapediatrics/article-abstract/2543281

Do You or Your Child have a Genetic Predisposition for Acetaminophen Detoxification Problems?

Since acetaminophen (Paracetamol, Tylenol) is one of the most commonly used pain relievers, proper metabolization of acetaminophen is critical to preventing toxicity and any resulting damage. Genetic mutations that cause an increase in the metabolite NAPQI or that limit the body’s ability to detoxify acetaminophen will make a person more susceptible to adverse effects from acetaminophen usage.  Our GPL-SNP1000 DNA Sequencing Profile analyzes 7 genes and 72 specific SNPs (mutations) related to acetaminophen toxification and detoxification.  The sample test results shown below are for the glutathione transferase genes.  GSTP1 is the major detox pathway for acetaminophen.  SNPs to GSTP1 can cause impaired detoxification and lead to increased risk of asthma.  The toxic metabolite of acetaminophen, NAPQI, is detoxed by glutathione.  NAPQI is formed in about 5% of the normal dose of acetaminophen.  If you take too much, your glutathione gets depleted and you can't detox it effectively.  The acetaminophen detox pathway is also shown below.   

 

Recent Media Coverage:

Here are several other recent articles about the possible health consequences of acetaminophen use, including those from major media outlets like the New York Times and well-known CNN medical correspondent, Dr. Sanjay Gupta:

http://www.cnn.com/videos/bestoftv/2014/02/25/ac-gupta-tylenol.cnn (Sanjay Gupta)

http://www.medicalnewstoday.com/articles/311949.php

http://www.medpagetoday.com/OBGYN/Pregnancy/59701 

http://www.newsobserver.com/living/health-fitness/article79256927.html

http://www.nytimes.com/2016/09/25/opinion/sunday/the-trouble-with-tylenol-and-pregnancy.html?_r=0

http://thenatpath.com/body/time-rethink-tylenol-childhood-vaccinations/

Summary:

There seems to be more than enough evidence to suggest avoiding acetaminophen for children when they are ill or when receiving vaccinations, and for women to avoid it when pregnant, whenever possible.  Knowing whether or not you or your child has any of the genetic mutations that affect acetaminophen detoxification is very important as well, and we can do that with our GPL-SNP1000 DNA Sequencing Profile

Alarming results of study: Many popular foods found to have glyphosate in them.

In case you missed our post from two weeks ago about the list of popular foods found to have glyphosate in them, we are sharing this incredibly important information again, along with a new interview about it all with Dave Murphy, Founder and Executive Director of Food Democracy Now!, who sponsored the study and below is the published list: 

Post1.png

{See the test results and full report by Food Democracy Now! and The Detox Project}. 

 

Here is the recent interview done by Ed Schultz on RT America with Dave Murphy, talking about these alarming findings:

Please share this information with everyone you know.  We have to be informed consumers, and the more people know about this and the dangers of glyphosate, the more we can have our voices heard that this is unacceptable!  For more information about the very real dangers of glyphosate (with many scientific references) and our urine
Glyphosate Test, click here.

GPL University Early Bird Pricing

Early bird pricing for our GPL University practitioner workshops August 6-7 in San Jose, CA ends this weekend!  Here are the details:

Organic Acids Testing Workshop – August 6

*Qualified attendees receive a FREE Organic Acids Test worth $299!

Genetic Testing & Toxic Chemical Testing Workshop – August 7

*Qualified attendees receive a FREE GPL-TOX (Toxic Organic Chemical Profile) worth $199! 

Attend both days and save $100!
*CME’s available.  Please see the Accreditation section of the workshop website for information. 

For all workshop details including the schedule, pricing, location information, and to register, go to www.GPLUniversity.com.  Hurry…early bird pricing ends this Sunday, July 10!

Got questions?  Email marketing@gpl4u.com or call 913.341.8949. 

The Unique Vulnerability of the Human Brain to Toxic Chemical Exposure

This recent article (below) brings into question the efficacy of hand sanitizers.  While there has been discussion for some time about how these products may actually help create “superbugs” that are resistant to our normal methods of sanitation (where just soap and water would be better), our primary concern here at GPL is about the toxic chemicals used in many hand sanitizers that are then absorbed into our bodies.  The most prominent of these antibacterial chemicals may be triclosan.  Our Lab Director, Dr. William Shaw wrote about the potential neurotoxicity of triclosan in hand sanitizers and other common products in this important article, originally published in the Journal of Orthomolecular Medicine:

http://www.greatplainslaboratory.com/articles-1/2015/11/13/the-unique-vulnerability-of-the-human-brain-to-toxic-chemical-exposure-and-the-importance-of-toxic-chemical-evaluation-and-treatment-in-orthomolecular-psychiatry?rq=unique%20vulnera

Additional Information Requested on Safety of Hand Sanitizers

http://www.mdlinx.com/internal-medicine/washington-report/2016/06/29/6737691?utm_source=in-house&utm_medium=message&utm_campaign=wr-im-june16##

Antidepressants Mostly Ineffective on Kids

Antidepressants Mostly Ineffective on Kids

A new study recently published in The Lancet and summarized in the two articles below says that based on meta-analysis, antidepressants don’t seem to be very effective for children or teens.  Because there are so many underlying biomedical problems that can contribute to symptoms of depression, from nutritional deficiencies and toxic chemical exposure to infections that release neurotoxins, it’s important to look for these problems with an Organic Acids Test (OAT) and a GPL-TOX Toxic Organic Chemical Profile.  Many of these problems can be addressed and treated naturally to relieve symptoms without the use of potentially harmful drugs

Impact of Antibiotic Treatment on Infant Gut Microbiome

Impact of Antibiotic Treatment on Infant Gut Microbiome

This study was conducted by researchers at Massachusetts General Hospital and published in the June 15 issue of Science Translational Medicine.  Its discoveries may help us better understand how the gut microbiome is established in us from the very beginning of life and how the combination of microbes in individual children may contribute to the risk of developing conditions like type 1 diabetes and inflammatory bowel disease.  A key finding of the study was that “Children who had been exposed to antibiotic treatment had a reduction in the diversity of their microbial population…”.

Impact of Antibiotic Treatment on Infant Gut Microbiome

https://www.sciencedaily.com/releases/2016/06/160615151708.htm

We know how important our gut flora diversity and balance can be to both for physical and mental health.  Here are several resources on our site for this.

It’s important to look for common infections like Candida that can disrupt our healthy gut flora and release toxins.  We also know that oral antibiotics can decrease healthy gut flora and give the opportunity for bad flora to take over, like Candida.  Proper gut balance can be restored by identifying infections via the Organic Acids Test, treating those infections with natural means when possible, and restoring the gut flora with high quality and diverse probiotics.  Read this article and view this webinar for more information on the benefit of probiotics:

http://www.greatplainslaboratory.com/articles-1/2016/2/22/the-role-of-probiotics-in-candida-and-clostridia-treatment-what-does-the-evidence-say?rq=probiotic

Addressing Common Nutritional Deficiencies in Autism

Addressing Common Nutritional Deficiencies in Autism

This recent article in Psychiatry Advisor talks about common nutritional deficiencies seen in children with autism.  Nutritional status is always one of the first things we want to look at in children who’ve been diagnosed with autism, which we do with the Organic Acids Test (OAT) and our Calcium + Magnesium Profile.  If these patients have already been put on a gluten-free and casein-free diet (often recommended for autism), and/or other elimination diets (due to the results of food allergy testing with our IgG Food Allergy Test), or if they are just picky eaters, we want to be sure they are getting enough calcium and other important vitamins and minerals, as nutritional deficiencies can make many symptoms of autism worse and create related problems like oxalate build-up.

Addressing Common Nutritional Deficiencies in Autism

http://www.psychiatryadvisor.com/autism-spectrum-disorders/autism-spectrum-disorder-and-nutrition/article/502452/?DCMP=EMC-PA_Update&cpn=&hmSubId=waZKTL2hQSY1&hmEmail=3SZg8SMVND5TQJRr0WNOjA2&NID=&dl=0&spMailingID=14738786&spUserID=MjgwMDM3NjI3MjQxS0&spJobID=801039118&spReportId=ODAxMDM5MTE4S0

We have a wealth of information on our website about nutrition and autism.  Check out all of these potential resources:

Seven Deadly Poisons and a Law that Won’t Protect You Fast Enough:

Seven Deadly Poisons and a Law that Won’t Protect You Fast Enough:

This article recently published by The Guardian mentions some of chemicals we test in GPL-TOX, our toxic organic chemical profile, including fire retardants, vinyl chloride, and phthalates.  For more information about GPL-TOX, go to the GPL-TOX test page.  Did you get a chance to see our Lab Director, Dr. William Shaw’s webinar, Toxic Chemicals and the Increasing Rates of Chronic Illnesses?  If not,  you may check that out here.

Seven Deadly Poisons and a Law that Won’t Protect You Fast Enough:

http://www.theguardian.com/commentisfree/2016/may/27/poison-chemical-health-law-toxic-regulation-harmful-substances?utm_content=buffer34c6b&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer