New Markers for the MycoTOX Profile


Welcome back to the GPL blog.  I have another exciting announcement and that is that we are adding four additional markers to our MycoTOX Profile, which screens for exposure to mycotoxins from mold.  Yet again, our laboratory scientists have shown why we are an industry leader in toxin exposure assessment.  These four new markers will now give us 11 markers on our revolutionary MycoTOX Profile.  These additional markers are also being added at no additional cost.

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Just by ordering the MycoTOX Profile you will get these four new markers in addition to the previous seven markers.  This test can be easily be added to the GPL-TOX (Toxic Non-Metal Chemical Profile) and the Organic Acids Test (OAT), all with just one first morning urine sample. 

Here are the new markers that we will be starting to report today. These four new markers will further help practitioners determine the underlying causes of their patients’ chronic health issues:

Gliotoxin (GTX) is produced by the mold genus AspergillusAspergillus spreads in the environment by releasing conidia which are capable of infiltrating the small alveolar airways of individuals.  In order to evade the body’s defenses Aspergillus releases Gliotoxin to inhibit the immune system.  One of the targets of Gliotoxin is PtdIns (3,4,5) P3.  This results in the downregulation of phagocytic immune defense, which can lead to the exacerbation of polymicrobial infections.  Gliotoxin impairs the activation of T-cells and induces apoptosis in monocytes and in monocyte-derived dendritic cells.  These impairments can lead to multiple neurological syndromes.

Mycophenolic Acid
Mycophenolic Acid (MPA) is produced by the Penicillium fungus.  MPA is an immunosuppressant which inhibits the proliferation of B and T lymphocytes.  MPA exposure can increase the risk of opportunistic infections such as Clostridia and Candida. MPA is associated with miscarriage and congenital malformations when the woman is exposed in pregnancy. 

Dihydrocitrinone is a metabolite of Citrinin (CTN), which is a mycotoxin that is produced by the mold species Aspergillus, Penicillium, and Monascus.  CTN exposure can lead to nephropathy, because of its ability to increase permeability of mitochondrial membranes in the kidneys.  The three most common exposure routes are through ingestion, inhalation, and skin contact.  CTN has been shown to be carcinogenic in rat studies.  Multiple studies have linked CTN exposure to a suppression of the immune response. 

Chaetoglobosin A
Chaetoglobosin A (CHA) is produced by the mold Chaetomium globosum (CG).   CG is commonly found in homes that have experienced water damage.   Up to 49% of water-damaged buildings have been found to have CG.  CHA is highly toxic, even at minimal doses.  CHA disrupts cellular division and movement.  Most exposure to CG is through the mycotoxins because the spores tend not to aerosolize.  Exposure to CHA has been linked to neuronal damage, peritonitis, and cutaneous lesions.

Species of Mold

These new markers are adding to our already revolutionary test. We will now be able to detect over 40 different strains of disease-causing mold.Here is a table that illustrates all of the different mold species that we can now detect:

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We are also instituting some new changes to our MycoTOX Profile test report.  We are moving all of the interpretations to the end of the report so that all of the results will fit on the first two pages.  In addition, we are changing the reportable range.  Since we launched this test we have analyzed thousands of samples.  By analyzing those results and comparing them to results from our Organic Acids Test, we now have a better understanding of what could be considered “normal values” for mycotoxins.  On our new report (seen below) you will see two numbers on the bar graph for each marker.  The number on the left is what we consider the maximum safe amount of mycotoxins a patient can have before symptoms may start to appear.  The number on the right is our 75% for our patients.  If your value is above this number then you have more mycotoxins than 75% of patients that have sent in samples.  These should be considered extremely elevated amounts and treatment is highly recommended. 

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Practitioner Training – GPL Academy Practitioner Workshops

I recommend to all practitioners that they attend our training workshops to help better understand how to evaluate the results from our tests, as well as to learn what treatments have been most effective.  Our GPL Academy workshops are great learning experiences.  At these events you can talk to our laboratory experts as well as discuss treatment plans with practitioners that we invite that are experts in their fields.  Please follow this link to find a workshop near you.

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