GPL4 Panel


The value of the GPL4 panel comes from the superior and comprehensive analysis it provides from a single urine sample and 3 blood tube samples testing for organic acids, vitamins and mineral levels, food allergies, metal toxicity and inflammation. The GPL4 panel provides an excellent assessment of an individual's metabolism and is targeted to find any irregularities that are directly related to numerous conditions.

Included in the GPL4 panel are:



The Organic Acids Test (OAT) provides a metabolic "snapshot" based on the products the body discards through the urine. These small, discarded organic acid molecules are byproducts of human cellular activity, the digestion of foods, and the metabolism of gastrointestinal flora. The Organic Acids Test includes 74 urinary metabolites, including 9 yeast markers, 8 bacterial markers, 3 oxalate marker, 3 Glycolytic cycle markers, 6 Krebs cycle markers, 7 neurotransmitter markers, 1 folate metabolism markers, 8 fatty acid oxidation markers, 8 vitamin markers, 3 indicators of detoxification, 14 amino acid metabolites and 1 bone metabolite. This makes it the most comprehensive Organic Acids test available anywhere.

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IgG (immunoglobulin G) testing is a useful guide for structuring elimination diets in many chronic conditions. Individuals with neurological, gastrointestinal, and movement disorders often suffer from IgG food allergies. IgG Food allergies do not usually release histamine but cause inflamation and elevated C-reactive protein. The 93 foods tested in the IgG Food Allergy Test w/ Candida can identify problem foods so they can be eliminated from the patient's diet.

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The metals test is important for measuring toxic metals that can impede development and normal brain functioning, as well as measuring levels of minerals essential for normal growth and good health. The results indicate levels of 39 toxic and essential elements, 5 ratios and includes an individualized interpretation.

Today, with increasing pollution levels, the presence of toxic metals in the environment is constantly growing. Chemical products, fertilizers, industrial paint, building materials, fish, silver dental fillings, and vaccines are just some of the sources of heavy metals in everyday life. Toxic metals may normally be present in the body in very low levels, but continuous exposure or metabolic abnormalities can cause accumulation of heavy metals in body tissues, and subsequently, in the brain.

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Phospholipase A2 (PLA2) is one of the key biochemical factors produced in the inflammatory response. It is commonly found in human tissues, as well as insect and snake venom. In infections, PLA2 can break down the phospholipids in the membranes of bacteria, fungi, and parasites leading to their death. However, inflammation, like many other biological processes often has negative effects. The same phospholipase that attacks infectious agents may also attack the cell membranes of the human host, damaging or killing those cells. In addition to PLA2 causing local cell damage, it may be transported by the blood vessels to other parts of the body, causing widespread tissue damage.

Studies have linked an increase in PLA2 activity with a variety of inflammatory diseases, including multiple sclerosis, rheumatoid arthritis, Crohn's disease, pancreatitis, ulcerative colitis, allergies, atherosclerosis and cardiovascular disease, lung, prostate, small intestine, and large intestine cancers, (with increased susceptibility to metastases), Candida infection, asthma, autism, chronic pulmonary obstructive disorder (COPD), and sepsis.

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Panel is available in the USA Only.



  • Evaluate energy production

  • Assess central nervous system function

  • Evaluate integrity of intestinal wall

  • Reveal high levels of GI yeast and bacteria

  • Detect nutritional and antioxidant deficiencies

  • Determine problems in fatty acid metabolism

  • Identify excess oxalates (oxalic acid)

  • Identifies possible food reactions that may be contributing to physical or mental symptoms

  • Determine if metal toxicity or mineral deficiency is contributing to a disorder

  • Monitor the effects of chelation (elimination of heavy metals from the body)

  • Identify levels of PLA2, an enzyme correlated with inflammatory diseases

  • Assess the likelihood of malabsorption or liver disease.


Urine: 10 mL of first morning urine before food or drink is suggested. Patient should avoid apples, grapes (including raisins), pears, cranberries and their juices 24 hours prior to specimen collection.
Dried Blood Spot (DBS): Five full circles of dried blood on the protein saver card is required.
Hair: 0.25 grams (approximately 1 tablespoon) of hair is the absolute minimum. 1 gram is preferred.
Serum: 2 mL of serum in a gold-topped SST is preferred. (Only required for the GPL4 Serum Panel)

Note: The elimination of a food will reduce the ability for our laboratory to detect antibodies (allergies) to that food.



  • 82679

  • 82670

  • 82677

  • 84144

  • 84402

  • 82626

  • 82530*4


  • 82670

  • 84144

  • 84402

  • 82626

  • 82530*4

Metals Hair

  • 82670

  • 84144

  • 84402

  • 82626

  • 82530*2


  • 84999

  • No Medicare Coverage


"I believe the Great Plains IgG Food Allergy Test is a phenomenal tool that I have implemented in my practice on a daily basis to help treat patients for a wide variety of symptoms like headaches, IBS, fatigue, abdominal pain, dermatitis, hair loss, joint pain, acne, thyroid disorders, and vitamin deficiencies. I believe I am a better physician due to this testing transforming my ability to properly diagnose and treat patients effectively."

–Bridget, M.D.