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Autism Spectrum Disorders

Deficient Cholesterol and Lithium: Common New Factors in Autism
Click here for printable brochure (PDF)

Oxalate Control is a Major
New  Factor in Autism


Click here for printable brochure (PDF)

GPL Information & Resources

Dr. Shaw's Book: Biological Treatments for Autism and PDD

Conference Presentation on Organic Acid Testing

Interview with Dr. Shaw

A Story on Autism Recovery

"The Yeast Problem & Bacteria By Products" By Dr. William Shaw

"Oxalates Control is a Major New Factor in Autism Therapy" By Dr. William Shaw

"Increased Urinary Excretion of Analogs of Krebs Cycle Metabolites and Arabinose in Two Brothers with Autistic Features" By Dr. William Shaw

"Assessment of Antifungal Drug Therapy in Autism by Measurement of Suspected Microbial Metabolites in Urine with Gas Chromatography - Mass Spectrometry" By Dr. William Shaw

"Porphyrin Testing and Heavy Metal Toxicity: Unresolved Questions and Concerns" By Dr. William Shaw

"Deficient Cholesterol: A Common New Factor in Autism" By Dr. William Shaw

"Lithium Deficiency: Common in Mental Illness and Social Ills" By Dr. William Shaw

Click here to view the Recommendations By Disorder Chart (PDF)

Autism Information

It is generally accepted within the autism community that autism is a behaviorally-based disorder.  Conventionally, diagnosis is based on observation of behavior and treatment focused on alleviating challenging behaviors.  A growing number of individuals within this expanding community also acknowledge that there exists an equally relevant biomedical component to the disorder that should not be overlooked in planning treatment programs for individuals who have an Autistic Spectrum Disorder (ASD).

At the Great Plains Laboratory Inc. (GPL), we specialize in providing comprehensive testing that can identify many common biomedical factors that affect the autistic community.  We are an industry leader in research and development of clinically significant tests for the autistic community.  Many of our tests are patented and are only available through GPL.  The director of our laboratory, Dr. William Shaw, PhD, is also the author of two books dedicated to the biomedical treatment of Autism and PDD.  His work is the most comprehensive and thorough evaluation of the scientific research available to date on the biochemical treatment of autistic spectrum disorders.  On this page, we have included a brief summary of the complex metabolic pathways which contribute to symptoms of Autism. If you are interested in learning more about biomedical research, we recommend reading Dr. Shaw’s book, Biological Treatments for Autism and PDD for more information.

Numerous clinical studies have shown that individuals diagnosed with ASD are predisposed to have decreased factors of immunity. These important physiological factors can lead to numerous complications that contribute to, and even cause, symptoms of Autism.  Some of the most common problems include the overgrowth of Candida and Clostridia, the inability to control environmental toxins, and the development of intolerances and/or allergies.  Each of these problems causes additional complications that make it more difficult for the body to gain balance.  These physical and environmental factors limit the available nutrients to the brain and body and create additional stress to chemical pathways.  In most cases, when these problems and complications are corrected, the patient’s symptoms are greatly improved. 

An insult to the immune system is difficult to determine simply based on symptoms alone.  The immune system is influenced by hundreds of different factors.  Many patients on the Autistic Spectrum exhibit only symptoms of autism.  Others will have eczema, loose stools, hyperactivity, rashes, dark circles under the eyes, and visible pain in addition to the cognitive and behavioral symptoms that rendered the diagnosis.  This is why diagnostic testing is so important to identify the problem.  Routine blood work often fails to identify the problem.  Biomedical testing can determine more specific abnormalities so the appropriate treatment can be determined.  Multiple tests can be very useful to pinpoint the most significant biochemical abnormalities so that treatment can be focused on the most important issues.  The tests included in the autism panel have been useful to people with autism of every degree of severity.  Parents and practitioners who want to embark on biomedical testing should first start with the tests included in this panel.

Autism Panel

Organic Acid Test
Urine Amino Acid Test
Comprehensive Stool Analysis
IgG Food Allergy Test
Advanced Cholesterol Panel
Copper / Zinc Profile
Metals Hair Analysis

Testimonials

"By just following the results of the food allergy test, where only low level of reactivity was reported in wheat and sugar, I just minimized these two elements from the environment under the supervision of our food nutritionist in Pakistan and within 15 days I have witnessed that my son has started to sit calmly for short noticeable time spans and his impatient violent movements also started to appear to have slightly eased out. Even this change has also been acknowledged by the special school.

After the receipt of the Gluten / Casein Peptide test report we plan to initiate comprehensive follow-up in the light of other reports with the help of our nutritionist and I am sure that the little progress signs witnessed in my son are quite encouraging and my son will soon be a part of normal life. Any parents of an ADHD / Autistic child in Pakistan can get in touch with me to have first hand feel of my personal experience through my cell No 0092-300-8414169."

Father of an autistic son from Pakistan


"I am sending this information in an attempt to describe the changes we have seen in our daughter, L...since beginning an anti-yeast program. We began this program December 7, 1995 after receiving her results from your organic acids test. Her original diagnosis is PDD-NOS.

After the initial reaction, we noticed immediate improvement with regard to her early morning moods. When she awakens now she is generally happy. Before the program her morning would begin with screams and tears or sometimes happiness--we never knew who would wake up in the morning. We also noticed dramatic increase in her social language. Before the program her verbalizations consisted of her needs. Now she actually uses her language to communicate experiences and to tattle on her older sister--very typical! We have not seen the giddy laughter since beginning the program and the rash under her lip has disappeared. We are extremely happy with the positive changes we have seen with L..."

Mother from Springfield, MO

"First of all I want to thank The Great Plains Laboratory, Inc. and report on a remarkable success. In April 2003 you performed the urine peptide test for Roan C. in connection with his diagnosis of autism. He tested VERY positive to gluten and casein intolerance, so very often a part of the autism spectrum. We immediately deleted these two items from his diet. Within a week, Roan went from almost no speech, to talking, an incredible decrease in stimming and tantrums, and other remarkable progress.

His progress was so remarkable that the head of special services in our local school system indicated that if Roan could handle full days of school, five days a week in a regular class setting during the summer 2003 session, he should be able to begin kindergarten in the fall session right on time! He completed summer school with flying colors and is right on track in his current kindergarten class. The first day of school, the class was observed by five different teachers, and no one was able to pick out the "autistic child"!!!!

I thought you would like you know what a big part you have played in this little boy's life.

Obviously the gluten/casein intolerance plays a large part in autism's manifestations, at least in Roan's case. He has accidentally grabbed his brother's "regular milk" on three occasions since April with no apparent results, but eating one breaded chicken nugget off his brother's plate and being fed ready-to-eat breakfast cereals twice at his father's caused the same reaction as a drug "come down"...the first occasion with the cereal lasting for THREE days. Roan's aide at school and the school nurse both verified this behavior. We are very, very watchful of his intake.

...We also had a 96 item food allergy scan done and Roan was allergic to apples, bananas, green beans, cabbage, egg yolks and whites and a few other things so we have also been avoiding them."

Roan's family, United States

 

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References

  1. Comi A, Zimmerman A.”Familial Clustering of Autoimmune Disorders and Evaluation of Medical Risk Factors in Autism” Journal of Child Neurology (1999) 14, 388-394
  2. Stubbs E, Crawford M, Burger D, Vanderark A. “Depressed Lymphocyte Responsiveness in Autistic Children” Journal of Autism and Developmental Disorders (1997) 7, 1573-3432
  3. Korvatska E, Van de Water J, Anders T, Gershwin M. “Genetic and Immunologic Considerations in Autism” Neurobiology of Disease (2002) 10, 69
  4. Warren R, Margaretten N, Pace N Foster A. “Immune Abnormalities in patients with Autism” Journal of Autism and Developmental Disorders (2005) 15, 189-197
  5. Warren R, Foster A, Margartten N. “Reduced Natural Killer Cell Activity in Autism” Journal of the American Academy of Child and Adolesent Psychiatry (1987) 26, 333-335

 

 


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