New Analytes for GPL-TOX

Today is a very exciting day for me.  I really love when we unveil new tests or improved tests.  Today is the latter.  Our scientists have worked very hard to make our tests the best in the industry.  We want to make sure that they can be as useful to the community as possible.  We also strive to make them as affordable as possible.  That is why I’m excited to announce the addition of eight new analytes to the GPL-TOX test at no addition cost.  Just by ordering our GPL-TOX you will get these eight new analytes in addition to the previous analytes and it is still just the one first morning urine sample that is needed.


Here are our new analytes, listed with the parent first and the metabolite we are measuring in parentheses.

Acrylamide N-acetyl-S-(2-carbamoylethyl)-cysteine

Acrylamide can polymerize to form polyacrylamide.  These chemicals are used in many industrial processes such as plastics, food packaging, nail polish, cosmetics, dyes, and treatment of drinking water.    Food and cigarette smoke are also two major sources of exposure.  Acrylamide has been found in foods like potato chips and French fries.  This is because asparagine, an important amino acid for central nervous system function, can produce acrylamide when cooked at high temperature in the presence of sugars.  Foods rich in asparagine include asparagus, potatoes, legumes, nuts, seeds, beef, eggs, and fish, so use caution when cooking these foods at high temperatures.   High levels of acrylamide can elevate a patient’s risk of cancer.  In addition, acrylamide is known to cause neurological damage. 

Acrylonitrile (N-acetyl(2-cyanoethyl)cysteine)

Acrylonitrile is a colorless liquid with a pungent odor.  It is used in the production of acrylic fibers, resins, and rubber.  Use of any of these products could lead to exposure to acrylonitrile.  Smoking tobacco and cigarettes is another potential exposure.  Exposure to acrylonitrile can lead to headaches, nausea, dizziness, fatigue, and chest pains.  The European Union has classified acrylonitrile as a carcinogen.

Diphenyl phosphate

This is a metabolite of the organophosphate flame retardant triphenyl phosphate (TPHP), which is used in plastics, electronic equipment, nail polish, and resins.  TPHP can cause endocrine disruption.  Studies have also linked TPHP to reproductive and developmental problems. 

Perchlorate

This chemical is used in the production of rocket fuel, missiles, fireworks, flares, explosives, fertilizers, and bleach.  Studies show that perchlorate is often found in water supplies.  Many food sources are also contaminated with perchlorate.  Perchlorate can disrupt the thyroid’s ability to produce hormones.  The EPA has also labeled perchlorate a likely human carcinogen.  Patients that are high in perchlorate can use a reverse osmosis water treatment system to eliminate the chemical from their water supply.

1,3 butadiene (N-acetyl (3,4-dihydroxybutyl) cysteine)

This is a chemical made from the processing of petroleum.  It is often a colorless gas with a mild gasoline-like odor.  Most of this chemical is used in the production of synthetic rubber.  1,3 butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease.  Individuals that come into contact with rubber, such as car tires, could absorb 1,3 butadiene through the skin.  The increased use of old tires in the production of crumb rubber playgrounds and athletic fields is quite troubling.  

Propylene oxide (N-acetyl(2,hydroxypropl) cysteine)

This chemical is used in the production of plastics and is used as a fumigant.   Propylene oxide is used to make polyester resins for textile and construction industries.  It is also used in the preparation of lubricants, surfactants, and oil demulsifiers,  as well as a food additive, an herbicide, a microbicide, an insecticide, a fungicide, and a miticide.  Propylene oxide is a probable human carcinogen. 

1-Bromopropane (N-acetyl (propyl) cysteine)

1-BP is an organic solvent used for metal cleaning, foam gluing, and dry cleaning.  Studies have shown that 1-BP is a neurotoxin as well as a reproductive toxin.  Research indicates that exposure to 1-BP can cause sensory and motor deficits.  Chronic exposure can lead to decreased cognitive function and impairment of the central nervous system.  Acute exposure can lead to headaches.

Ethylene oxide ( N-acetyl(2-hydroxyethl)cysteine)

Ethylene oxide is used in many different industries including agrochemicals, detergents, pharmaceuticals, and personal care products.  Ethylene oxide is also used as a sterilizing agent on rubber, plastics, and electronics. 

Chronic exposure to ethylene oxide has been determined to be mutagenic to humans.  Multiple agencies have reported it as a carcinogen.  Studies of people exposed to ethylene oxide show an increased incidence of breast cancer and leukemia.  Caution is needed with ethylene oxide because it is odorless at toxic levels. 

I think these new compounds are going to make the GPL-TOX profile that much more useful.  If you are concerned about your toxic burden, we believe that this test will give you the most comprehensive assessment of your exposure.  I really hope we’ve created a test that can be a useful tool in achieving better health for you and your patients.